아산병원 피부과 한 승석 선생님께
안녕하십니까. 저는 서울의대 암연구소와 생화학 교실에 교수로 재직 중인 정 준호 라고 합니다. 우선 영문을 보고 성함을 추측한 것이라서 혹시 성함이 틀렸으면, 용서해 주시면 감사하겠습니다.
서울의대 암연구소, 국립암센터, 일본 국립암센터는 매년 closed meeting인 한일암 워크샾을 진행하고 있습니다. 올해는 12월 18-19일간 일본 가나자와에서 있을 예정입니다. 선생님께서 최근 Br J Dearmatology에 발표하신 논문을 이 meeting에서 발표하여 주시면 무척 영광이겠습니다. 왕복 여행 경비는 서울의대 암연구소가, 체류비는 일본 국립암센터에서 제공할 예정입니다. 무척 죄송합니다만, 제가 오늘 중으로 참가자를 확정하고, 초록을 보내야 하는 상황이라서, 암연구소 측에서 오늘 선생님께 직접 전화나 문자로 연락드리도록 arrange 하겠습니다. 양해를 구합니다. 죄송합니다.
정 준호 올림
가. 일 시 : 2009.12.18(금) ~ 12.19(토) (2박3일)
나. 장 소 : Crowne Plaza ANA, KANAZAWA (16-3 SHOWA-MACHI KANAZAWA, ISHIKAWA, 920 8518 JAPAN )
다. 주 제 : "Translational cancer research and progress in colorectal cancer" 로서 기초 분야는 이 행성 연구, 임상 분야는 대장암 분야
라. 제출서류 : 발표할 초록
마. 체재비 등 기타
- 숙박비 및 왕복 여비를 지원
DERMATOPATHOLOGY
Investigation of papulopustular eruptions caused by cetuximab treatment shows altered differentiation markers and increases in inflammatory cytokines
S.S. Han*, M. Lee*, G.H. Park*†, S.H. Bang‡, Y.K. Kang§, T.W. Kim§, J.L. Lee§, H.M. Chang§ and M.H. Ryu§
*Department of Dermatology, Asan Medical Center, SongPa-Gu PyongNab-Dong, Seoul 138-736, Korea
†Department of Dermatology, University of Ulsan College of Medicine, Seoul, Korea
‡Asan Institute for Life Science, Seoul, Korea
§Department of Oncology, Asan Medical Center, SongPa-Gu PyongNab-Dong, Seoul 138-736, Korea
Correspondence to Seung Seog Han.
E-mail: xxxxxxx@gmail.com
Conflicts of interest
None declared.
Copyright Journal Compilation © 2009 British Association of Dermatologists
KEYWORDS
cetuximab • epidermal growth factor • papulopustular eruption • xerosis
ABSTRACT
Background Epidermal growth factor receptor (EGFR) critically regulates tumour cell division, survival and metastasis. Agents that inhibit EGFR have been used in the treatment of advanced-stage malignancies, but cause variable cutaneous side-effects, most often papulopustular eruptions and xerosis.
Objectives We assayed expression of inflammatory cytokines [interleukin (IL)-1α, tumour necrosis factor (TNF)-α, interferon (IFN)-γ, human leucocyte antigen (HLA)-DR and intercellular adhesion molecule (ICAM)-1], differentiation markers (filaggrin, involucrin and loricrin) and phosphorylated EGFRs (pEGFRs) in papulopustular eruptions to determine the association between these markers and the eruptions caused by cetuximab.
Patients/methods Twelve papulopustular lesion biopsies were selected from patients with colon cancer who had received cetuximab treatment. Immunohistochemistry and immunofluorescence with a confocal laser scanning microscopy were performed.
Results Filaggrin expression decreased and expression of involucrin, various inflammatory markers (IL-1α, TNF-α, ICAM-1 and HLA-DR) increased and the expression of pEGFR was markedly downregulated in papulopustular eruptions. In perilesions, decreased pEGFR expression was noted in hair follicles compared with interfollicular epidermis. The increase of IL-1α and TNF-α was observed in perilesions as in the lesions.
Conclusions The early inflammatory events (IL-1α and TNF-α expression) seen, and the lack of pEGFR in perilesional follicles, indicate that inflammatory events induced by EGFR inhibition may initiate papulopustular eruptions along with the altered differentiations. The decrease of filaggrin may contribute to the pathogenesis of the xerosis caused by cetuximab.
Accepted for publication 21 August 2009
Junho Chung M.D., Ph.D.
Chairman & Professor
Department of Biochemistry and Molecular Biology
Seoul National University School of Medicine
